The South and South-West Asia region has made considerable progress in improving economic and social welfare over the last decade. Water resources have contributed greatly to this transformation through measures such as water and sanitation hygiene (WASH), provision of basic services and agricultural expansion. Since the adoption of the 2030 Agenda for Sustainable Development and the Sustainable Development Goals (SDGs), progress has been made to elevate water issues at the national and regional level. However, access to sustainable water resources is increasingly threatened by several issues like pollution, growing populations, increasing water demands, and climate change. While there has been a substantial effort to increase aid to the least developed countries for water supply and sanitation, people throughout the subregion still lack access to safely managed drinking water and sanitation services. Despite progress in some components of SDG 6, such as the reduction of open defecation, overall development is not on track to achieve the specific target goals by 2030. Continuous water availability—both in sufficient quantity and adequate quality—is fundamental to the expansion of safe drinking water services. The most notable threat to progress of Goal 6 is water stress. In the effort to ensure food security for growing populations, the status of available freshwater resources has largely been neglected in some of the most consequential parts of the SSWA region. It’s essential for the subregion to act to reverse negative trends for target 6.6, protect and restore water-related ecosystems. Regional cooperation can ensure moving towards the targets of Goal 6, especially target 6.5.2, transboundary water cooperation. JEL Codes(s): I32, L97, N15, O20, P18, Q53, R Keywords: SDG progress, South and South-West Asia, SDG-6, Clean Water, Water Management, Water Stress, Hygiene